Sunday , May 19 2024

Regeneron Jobs – Scientist, Protein Biochemistry

Website Regeneron

Job Description:

The Protein Biochemistry Group at Regeneron is seeking a biophysical chemist Scientist to provide analytical protein characterization through the use of ground-breaking technologies. You will be responsible for providing in-depth biophysical and biochemical characterization of proteins to support development programs in our pipeline. You will be expected to take on a role in applying a diverse array of sophisticated biophysical techniques to deepen our knowledge of labeled proteins and their heterogeneity to support regulatory submission. This is a permanent position in the Protein Biochemistry Group that will be responsible for development, purification and characterization of the critical protein reagents.

Job Responsibilities:

  • Manage and mentor research associates and work as part of a collaborative team to meet project milestones
  • Develop site-specific labeling methods as an orthogonal to amine coupling
  • This position will provide the opportunity to make visible contributions to a variety of projects while interacting with a knowledgeable and dedicated multidisciplinary team
  • Maintain documentation of experimental procedures and results in a laboratory notebook per established guidelines
  • Provide timely support to internal and external collaborators and present results and reports at various meetings
  • Manage stability testing program for critical protein reagents
  • Provide well characterized protein reagents to other departments in the company and to collaborators
  • Develop and implement new analytical techniques to assess the stability of labeled protein reagents including freeze/thaw studies; optimize labeling conditions and formulation buffers to improve reagent stability
  • Conduct experiments to determine quality attributes of labeled drugs that impact downstream assays
  • Purify and characterize labeled and unlabeled proteins and anti-drug antibodies at both small and large scale

Job Requirements:

  • This role requires a PhD in Biochemistry, Bioengineering or related discipline with 0-2 years of experience with an emphasis on protein purification and characterization. Demonstrated solid proficiency in various protein purification techniques including affinity, ion exchange, gel filtration, HIC; strong FPLC/liquid chromatography experience.
  • Experience with protein characterization techniques such as SDS-PAGE, Western blot, ELISA, Kinetic and Binding studies using SPR/BLI technology, CE-SDS, IEF/cIEF, SEC.
  • Experience with additional analytical techniques, such as LC-MS, SEC-MALS, DLS, and DSC is a plus.
  • Experience in labeling proteins with biotin, ruthenium, alexa fluor and other dye labels preferred.
  • Ability to critically analyze and troubleshoot scientific problems.
  • A high level of scientific initiative and ability to multi-task, prioritize work and handle multiple projects at once.
  • Ability to work independently but also within a collaborative team environment and have flexibility to work on changing priorities.
  • Excellent verbal and written communication skills.
  • You have strong initiative and aim to complete challenging tasks and learn new technologies.
  • You are capable of multi-tasking, working both independently and within a team environment.

Job Details:

Company:  Regeneron

Vacancy Type:  Full Time

Job Location: Oakland, CA, US

Application Deadline: N/A

Apply Here

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